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    Structural Biochemistry/Viagra (Sildenafil Citrate) - Wikibooks, open ...

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    The medical uses for Sildenafil Citrate are sexual dysfunction, pulmonary hypertension, ... Its annual sales account for over a billion dollars each year. Sildenafil was synthesized by a group of pharmaceutical chemists working at Pfizer's ... Major drugs that are believed to cure ED are Viagra, Cialis, and Levitra and are under ...

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    Its annual sales account for over a billion dollars each year. Sildenafil acts by inhibiting cyclic guanosine monophosphate(cgmp)-specific phosphodiesterase type 5, an enzyme which is responsible for degradation of cgmp in the corpus cavernosum in the penis. The main function of the drug is to inhibit the enzyme that degrades cgmp, a regulator of blood flow to the penis.

    Therefore, doctors do not recommend consuming alcoholic beverages while taking the drug. It is estimated than 70 of the population in united states suffer from erectile dysfunction due to an underlying disease like kidney condition. .

    It became the first oral treatment accepted by the fda to treat med. Effective treatment in such scenarios include injecting medication into the penis, changing ones lifestyle my reducing the amount of cigarette or alcohol consumed. Sildenafil is metabolised by liver enzymes and excreted by both the liver and kidneys.

    Vacuum pumps are also helpful since it encourages blood flow and makes the penis erect. Vasodilation of the intimal cushions allows for an increased blood flow into the spongy tissue of the penis, thus, causing the erectile tissue to expand and create an erection. It was discovered by accident while attempting to produce a drug to treat coronary heart disease.

    Without sexual stimulation, and therefore lack of activation of the nocgmp system, sildenafil should not cause an erection. If taken with a high-fat meal, absorption is reduced the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third. Sildenafil causes the same effect on the body which can cause a dramatic increase in the potential of suffering these effects.

    Discover new insights into neuroscience, human behavior and mental health with scientific american mind. This molecule is very sensitive to temperature and light therefore it has to be kept at room temperature between 15-30 degrees c away from moisture or heat. However, there are many other causes of ed such as diabetes, hormonal deficiencies, and neurological problems. First, nitric oxide (no) in the corpus cavernosum of the penis binds to guanylate cyclase receptors. Viagra (sildenafil citrate) is formulated as blue, film-coated rounded-diamond-shaped tablets the mechanism of viagra (sildenafil) in the body involves the protection of cyclic guanosine monophosphate (cgmp) from degradation by cgmp-specific phosphodiesterase type 5 (pde5) in the corpus cavernosum of the male penis.


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    How Viagra Works. The famous blue pill acts on an enzyme that can block erections. By Dwayne Godwin, Jorge Cham on November 1, 2015. Share on ...

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    Because penile erection is a hydraulic effect of blood rushing into the penis and retained in sponge-like pores, erectile dysfunction is cause by circulatory mishap. This results in an increase of cgmp, which promotes vasodilation of the intimal cushions of the helicine arteries. . It became the first oral treatment accepted by the fda to treat med. The molecular structure of sildenafil is similar to that of cgmp and acts as a competitive binding agent of pde5 in the corpus cavernosum, resulting in more cgmp and better erections.

    Once cgmp levels deplete, then the intimal cushions of the helicine arteries are not able to dilate to allow more blood flow. Ethanol thins blood and dilates blood vessels which can cause dizziness, rapid heart rate, and low blood pressure. Sildenafil acts by inhibiting cyclic guanosine monophosphate(cgmp)-specific phosphodiesterase type 5, an enzyme which is responsible for degradation of cgmp in the corpus cavernosum in the penis. Erectile dysfunction is a sexual dysfunction which is shown by the inability to maintain an erection of the penis during sexual intercourse. Sildenafil causes the same effect on the body which can cause a dramatic increase in the potential of suffering these effects.

    However, there are many other causes of ed such as diabetes, hormonal deficiencies, and neurological problems. First, nitric oxide (no) in the corpus cavernosum of the penis binds to guanylate cyclase receptors. It was shocking to know that only 33 out of those only look for some advice or medical assistance, because this is the reason for 35 of the breakdown of relationships. The medical uses for sildenafil citrate are sexual dysfunction, pulmonary hypertension, and altitude sickness. In 1998, the drug viagra was introduce as an effective way to treat male erectile dysfunction (med). It is estimated than 70 of the population in united states suffer from erectile dysfunction due to an underlying disease like kidney condition. Sildenafil was synthesized by a group of pharmaceutical chemists working at pfizers research facility in england. It has quickly become one of the most popular and most prescribed drugs in the world. It was discovered by accident while attempting to produce a drug to treat coronary heart disease. Losing weight, and following an exercise regime that improves blood flow also helps.

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    Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile ... Sildenafil and other PDE5 inhibitors are used off-label to alleviate .... Other drugs that operate by the same mechanism include tadalafil (Cialis) and ... In 2000, Viagra sales accounted for 92% of the global market for prescribed ...
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